$35.00
Manufacturer: Germany
Superficial wounds with little exudate and superinfection caused by thyrotricin-sensitive pathogens such as lacerations, scratches, abrasions.
Description
Tirozur (thyrotricin) skin powder 1 mg/g. 20 g. vial
Composition
active substance: thyrotricin,
1 g of powder contains 1 mg of thyrotricin;
Excipients: lactose monohydrate, macrogol, colloidal anhydrous silica.
Dosage form
Skin powder.
Main physical and chemical properties: white loose powder.
Pharmacotherapeutic group
Antibiotics for topical use.
ATX code D06A X08.
Pharmacological properties
Tyrothricin is a compound of various cyclic and linear polypeptides that exhibit antibacterial activity and are formed as endotoxin by the anaerobic spore-forming Bacillus brevis. This compound contains up to 70-80% Tyrocidin (a basic cyclic decapeptide) and up to 20-30% gramicidin (a neutral linear pentadecapeptide).
It is mainly active against the gram-positive bacteria Staph. aureus MSSA, Staph. aureus MRSA, Staph. Haemolyticus, Strep. Pyogenes, Strep. Viridans, Enterococcus faecalis, Diplococcus pneumoniae, Corynebact. spp. , Neisseria meningitides of some strains of Neisseria gonorrhoeae, fungi and Trichomonas, as well as some gram-negative bacteria and many types of fungi, including Candida.
Tyrothricin has a dose-dependent bacteriostatic or bactericidal effect against microorganisms such as Clostridia.
Isolation of substances such as nitrogen and phosphates from bacterial cells ensures the effectiveness of thyrocidine. Like cationic detergents, Tyrocidin destroys the osmotic barrier of bacterial cell membranes. Due to the direct effect on the bacterial cell wall, the effect of the drug is not limited to inhibition of cell growth or division, it also causes the bactericidal effect of thyrocidine.
In addition, gramicidins form cation channels in the cell membrane of bacteria, which leads to their loss of potassium and, as a result, to a change in the intracellular concentration of cations and cytolysis. A component such as gramicidin further causes a rupture of phosphorylation processes in the cellular respiration chain.
Through a special mechanism of action of tyrothricin, not observed in systemic antibiotics, cross-resistance does not occur.
Tirozur skin powder accelerates the healing process by cleaning the bottom of the wound, as well as stimulating the processes of granulation and epithelialization.
It is not known to what extent tyrothricin can be absorbed systemically. High concentrations were found in the stratum corneum (after application to an intact surface) and directly in the wound.
Indications
Superficial wounds with insignificant exudate and the presence of superinfection caused by pathogenic microorganisms sensitive to tyrothricin, such as lacerations, scratches, abrasions.
Contraindications
Hypersensitivity to drug components.
Use during pregnancy and lactation
There are no data on the effect of Tirozur skin powder during pregnancy. Adequate studies of the effect of tyrothricin on reproductive function in animals have not been conducted. The degree of systemic absorption of tyrothricin after its application on the skin surface is unknown, so it should be used with caution during pregnancy.
Method of administration and dosage
Once or twice a day, sprinkle the affected skin with a thin layer of powder and, if necessary, cover them with a bandage.
The duration of treatment is determined individually, depending on the course of the disease. If there is no improvement after a week of using the drug, then the treatment should be reviewed.
Children
If necessary, Tirozur skin powder can be used for children of any age.
Overdose
No cases of overdose have been reported.
Side effects
Skin irritation, allergic reactions including erythema, urticaria, contact dermatitis.
Recent Reviews