Description
Tolevas (Atorvastatin) Coated Tablets 20 mg. №30
Ingredients
- Active ingredient: Atorvastatin 20 mg.
- Other ingredients: lactose monohydrate, microcrystalline cellulose, croscarmellose sodium, colloidal silicon dioxide, magnesium stearate, hypromellose, talc, titanium dioxide, and polyethylene glycol.
Dosage
Recommended dosage: The usual starting dose is 10-20 mg once daily. Dosage adjustments should be made at intervals of 2-4 weeks. The maximum dose is 80 mg once daily.
Indications
Tolevas (Atorvastatin) coated tablets are indicated for the treatment of hypercholesterolemia and mixed dyslipidemia. They are also used for the prevention of cardiovascular diseases in patients with multiple risk factors.
Contraindications
Do not use Tolevas (Atorvastatin) coated tablets if you have a known hypersensitivity to any component of the product. They are contraindicated in patients with active liver disease or unexplained persistent elevations of serum transaminases.
Directions
Take Tolevas (Atorvastatin) coated tablets orally with or without food, as directed by your healthcare provider. Swallow the tablet whole with a glass of water. Do not break or crush the tablet.
Scientific Evidence
Atorvastatin, the active ingredient in Tolevas tablets, is a potent inhibitor of HMG-CoA reductase, the enzyme responsible for the synthesis of cholesterol in the liver. Clinical trials have demonstrated the efficacy of atorvastatin in reducing LDL cholesterol levels and decreasing the risk of cardiovascular events. A study published in the New England Journal of Medicine showed that atorvastatin significantly reduced the incidence of major cardiovascular events in patients with coronary heart disease.
Additional Information
- Pharmacological Effects: Atorvastatin works by inhibiting the enzyme HMG-CoA reductase, which plays a key role in cholesterol synthesis. By lowering LDL cholesterol levels and increasing HDL cholesterol levels, atorvastatin helps reduce the risk of atherosclerosis and cardiovascular events.
- Clinical Trials: Several large-scale clinical trials, such as the ASCOT-LLA study and the TNT study, have demonstrated the efficacy of atorvastatin in reducing cardiovascular morbidity and mortality. These trials have established atorvastatin as a cornerstone therapy for the prevention of cardiovascular diseases.
