Description

Topiromax 100 (topiramate) Coated Tablets 100 mg. №30

Ingredients

Active ingredient: Topiramate 100 mg.
Other ingredients: Microcrystalline cellulose, pregelatinized starch, sodium starch glycolate, colloidal silicon dioxide, magnesium stearate, hypromellose, polyethylene glycol, titanium dioxide, and iron oxide.

Dosage

Recommended dosage: The usual starting dose is 25 mg once daily in the evening. The dose is then increased by 25-50 mg every week based on the response. The maximum recommended dose is 400 mg per day.

Indications

Topiromax 100 (topiramate) tablets are indicated for the treatment of epilepsy in adults and children. It is also used for the prevention of migraine headaches in adults.

Contraindications

Do not use Topiromax 100 tablets if you are allergic to topiramate or any of the inactive ingredients. It is contraindicated in patients with metabolic acidosis, kidney stones, and certain types of glaucoma.

Directions

Take Topiromax 100 tablets exactly as prescribed by your healthcare provider. Swallow the tablets whole with a full glass of water. Do not crush or chew the tablets.

Scientific Evidence

Topiramate, the active ingredient in Topiromax 100 tablets, has been extensively studied for its efficacy in the treatment of epilepsy and migraine. Research published in the *Journal of Neurology* has shown that topiramate is effective in reducing the frequency of seizures in patients with epilepsy. Additionally, a study in the *Journal of Headache and Pain* demonstrated the effectiveness of topiramate in preventing migraine headaches.

Additional Information

It is important to follow your healthcare provider’s instructions carefully when taking Topiromax 100 tablets. **Do not** suddenly stop taking the medication without consulting your doctor, as it may lead to an increase in seizures or migraines. Inform your healthcare provider about any other medications you are taking to avoid potential drug interactions.

Pharmacological Effects: Topiramate works by affecting the activity of neurotransmitters in the brain, such as gamma-aminobutyric acid (GABA), to reduce abnormal electrical activity that can lead to seizures. It also has effects on voltage-gated sodium channels and calcium channels, further contributing to its antiepileptic and antimigraine properties.

Clinical Trials: Clinical trials have demonstrated the efficacy of topiramate in reducing seizure frequency in patients with epilepsy and decreasing the frequency and severity of migraine attacks. A study published in the *New England Journal of Medicine* showed that topiramate was well-tolerated and effective in reducing the frequency of migraine headaches.