Torsid (torasemide) solution for injections ampoules 5 mg/ml. 4 ml. №5

Description

Torsid (torasemide) solution for injections ampoules 5 mg/ml. 4 ml. №5

Composition

active substance: torasemide;

1 ml of solution contains torasemide in terms of 100% dry matter 5 mg;

Excipients: polyethylene glycol 400, tromethamine, sodium hydroxide, water for injections.

Dosage form

Solution for injection.

Basic physical and chemical properties: transparent colorless liquid practically without mechanical inclusions.

Pharmacotherapeutic group

Diuretics. Highly active diuretics.

ATX code C0ZS A04.

Pharmacological properties

Torasemide acts as a saluretic, its action is associated with inhibition of renal absorption of sodium and chlorine ions in the ascending part of the Henle loop.

In humans, the diuretic effect quickly reaches its maximum within the first 2-3 hours after intravenous and oral administration, respectively, and remains constant for almost 12 hours. In healthy probands, a dose-proportional logarithm of diuresis increase (diuretic loop activity) was observed in the dose range of 5–100 mg. Increased diuresis was observed even when other diuretics, such as distally effective thiazide diuretics, no longer had the desired effect, such as in renal insufficiency. Due to this mechanism of action, torasemide reduces edema. In the case of heart failure, torasemide reduces the manifestations of the disease and improves myocardial function by reducing pre- and postload.

Indications

The drug Torsid solution is from the group of diuretics, fast acting. It has the ability to eliminate puffiness, which is relevant for the treatment of hypertension, which helps to lower blood pressure. May be used to reduce sweating and swelling caused by heart failure.
The increase in the diuretic effect of the drug Torsid solution is in direct proportion to the size of the dose taken. A distinctive quality is that torasemide has a diuretic effect even in the absence of the effect of other drugs, in particular, with impaired renal function. A decrease in the amount of calcium in the arterial walls, in turn, decreases peripheral vascular resistance. Thanks to this effect of the drug, there is a decrease in blood pressure, facilitating the work of the heart.

Contraindications

Contraindicated in case of allergy to its components, lactose, as well as sulfonylurea class drugs. It is not used for low blood pressure, impaired renal function, anuria, imbalance in water and electrolyte balance.
It is recommended to refrain from drinking alcohol during therapy with this drug. It should also take into account its ability to reduce the effectiveness of drugs that are taken for hypoglycemia, as well as reduce the effect of epinephrine.
Application during pregnancy and lactation

The use of this drug is contraindicated both when carrying a child and during lactation.

Method of administration and dosage

In acute cases, treatment is started with an intravenous injection of 2 milliliters of the drug (10 milligrams in equivalent). It is permissible to double the dose if necessary. The maximum dose is 8 mg. The drug is administered intravenously, in a stream, very slowly. Intra-arterial administration is prohibited!
The drug should not be administered intravenously for more than 7 days. In the future, it is necessary to transfer the patient to oral administration.

Overdose

Overdose cases are poorly understood. Theoretically, strong urination may occur, which entails the risk of dehydration, the occurrence of amentive syndrome, drowsiness, a sharp drop in pressure, and indigestion.
It is recommended to restore water balance, replenish potassium in the body. At the risk of anaphylactic shock, appropriate therapy is carried out – the patient is placed in a horizontal position, oxygen therapy is prescribed, and epinephrine is administered.

Side effects

Side effects may occur, including bowel upset, hyperglycemia, hypoglycemia, and disturbed water-electrolyte balance. The cardiovascular system can react with cardiac ischemia, hypercreatininemia. Allergic skin reactions are possible.