Tos-mai (dextromethorphan hydrobromide) tablets №16

Description

Tos-mai (dextromethorphan hydrobromide) tablets №16

Composition

active substances: dextromethorphan hydrobromide, benzocaine, potassium guaiacol sulfonate, sodium benzoate;

1 tablet contains 2 mg of dextromethorphan hydrobromide, 0.2 mg of benzocaine, 15 mg of sodium benzoate, 35 mg of potassium guaiacol sulfonate;

Excipients: mannitol (E 421), povidone, talc, magnesium stearate, anise essence, menthol, saccharin sodium

Dosage form

Tablets.

Main physical and chemical properties: white tablets with patches, diameter 13 mm.

Pharmacotherapeutic group

Antitussives and expectorants.
ATX code R05F B.

Pharmacological properties

This drug Tos-mai  is a combination drug that is used to treat a cough symptom.
The substance dextromethorphan has an antitussive effect due to its ability to inhibit the cough center. As a result, it is effective for coughs of any etiology.
It has the property of selectively affecting the cough center, which is located in the central nervous system. Does not inhibit respiratory function if consumed in the recommended therapeutic dosages.
Has no narcotic, analgesic or hypnotic effect.
Benzocaine is a highly active local anesthetic that is not resorptive. It is able to reduce the ionic permeability of nerve endings. Reduces pain, sore throat.
Potassium guayacolsulfonate is an expectorant. It dilutes phlegm, bronchial secretions, thereby facilitating its discharge from the respiratory system, increases the activity of the cilia of the flickering epithelium of the respiratory tract.
Produces some antiseptic and anesthetic effects.
Sodium benzoate is a direct-acting expectorant drug. Increases the secretion of the bronchi, dilutes phlegm, and helps the release of phlegm from the respiratory tract.
It has mild antibacterial and antifungal properties.

Indications

This drug Tos-mai is used to treat uncomplicated dry, irritating and unproductive cough that occurs due to minor inflammation of the throat or bronchi with a cold or inhalation of substances that irritate the mucous membrane of the lower respiratory tract.
It is also used in preparation for a bronchoscopy procedure.
Dextromethorphan inhibits the cough reflex. Being an analogue of codeine, it produces a slight analgesic effect, it can cause some addiction if taken longer and in higher dosages than prescribed by the instructions for the drug.
Acts on the cough center of the medulla oblongata, increasing the threshold of the cough reflex.

Contraindications

Not applicable if the patient has hypersensitivity (allergy) to one of the components that make up the drug.
Also does not apply if a person has:

• respiratory failure;
• bronchial asthma;
• emphysema of the lungs.

In addition, the drug should not be used in patients receiving monoamine oxidase (MAO) inhibitors such as procarbazine, selegiline.
In pediatric practice, it is used over the age of 6 years.
Care should be taken when prescribing for the treatment of patients with hepatic insufficiency.

Application during pregnancy and lactation

It is not used to treat pregnant or lactating women.

Method of administration and dosage

This drug Tos-mai is administered orally.
Adults and children 12 years of age and older take 1-2 tablets 4-6 times a day (but not more than 16 tablets per day).
Children aged 6-12 years take 1 tablet 4 times a day (but not more than 8 tablets per day).
The maximum duration of treatment is 7 days.
For more effective absorption of the drug, it is advisable to dissolve the tablets in the mouth.

Overdose

Overdose of the specified drug has not been described and observed at the moment.
Can theoretically cause symptoms such as:

• dizziness;
• respiratory depression;
• lowering blood pressure;
• tachycardia;
• dyspeptic disorders.

Treatment of symptoms is recommended.
A specific antidote, naloxone, has been identified. The specified drug is permissible to use if the dosage exceeded the maximum permissible by 100 or more times.

Side effects

Therapy with this drug, in case of manifestations of a hypersensitivity reaction, can cause allergic reactions in the form of:

• itching, urticaria;
• skin rash, edema;
• drowsiness, dizziness;
• nausea, abdominal pain, other dyspeptic symptoms.

If you experience any unusual side effects as a result of taking this drug, you should consult your doctor about possible changes in the treatment regimen.