Description

Trenaxa 250 (Tranexamic Acid) Coated Tablets 250 mg. №12

Ingredients

Active ingredient: Each coated tablet contains 250 mg of Tranexamic Acid.

Dosage

Dosage: The usual dosage of Trenaxa 250 is 500 mg to 1500 mg daily in divided doses.

Indications

Indications: Trenaxa 250 is indicated for the treatment of heavy menstrual bleeding, short-term management of hemorrhage, and prevention of excessive bleeding during surgery.

Contraindications

Contraindications: Do not use Trenaxa 250 in patients with a history of hypersensitivity to tranexamic acid, subarachnoid hemorrhage, and color vision disturbances.

Directions

Directions: Swallow the tablets whole with a glass of water. Do not crush or chew the tablets.

Scientific Evidence

Tranexamic acid, the active ingredient in Trenaxa 250, works by inhibiting the breakdown of blood clots, thereby reducing bleeding. Studies have shown that tranexamic acid is effective in reducing blood loss during surgery and in the treatment of heavy menstrual bleeding. Research published in the Journal of Thrombosis and Haemostasis demonstrated the efficacy of tranexamic acid in various clinical settings.

Additional Information

It is important to note that Trenaxa 250 should be used with caution in patients with a history of thromboembolic events. Consult a healthcare professional before using this medication, especially if you are pregnant or breastfeeding.

Pharmacological Effects

Tranexamic acid exerts its pharmacological effects by inhibiting the activation of plasminogen to plasmin, which plays a crucial role in the breakdown of blood clots. By preventing this process, tranexamic acid helps in maintaining hemostasis and reducing excessive bleeding. This mechanism of action makes it a valuable agent in various clinical scenarios where controlling bleeding is essential.

Clinical Trials and Comparative Effectiveness

Clinical trials have demonstrated the efficacy of tranexamic acid in various settings, including trauma, surgery, and menorrhagia. Comparative studies have shown that tranexamic acid is as effective as other antifibrinolytic agents but with a more favorable side effect profile. Research by Morrison et al. (2018) highlighted the benefits of tranexamic acid in reducing blood loss and transfusion requirements in surgical patients.

For more detailed information on the pharmacological effects and clinical trials of Trenaxa 250, consult your healthcare provider.