Description

Zanidip (lercanidipine hydrochloride) Coated Tablets 20 mg. №28

Ingredients

Active ingredient: Each tablet contains 20 mg of lercanidipine hydrochloride.

Dosage

Dosage: The recommended dose is one tablet per day, preferably taken in the morning before breakfast.

Indications

Indications: Zanidip tablets are indicated for the treatment of essential hypertension in adults.

Contraindications

Contraindications: Do not use Zanidip if you are allergic to lercanidipine or any other ingredients in the tablets.

Directions

Directions: Swallow the tablet whole with a glass of water. Do not crush or chew the tablet.

Scientific Evidence

Zanidip (lercanidipine hydrochloride) has shown significant efficacy in lowering blood pressure in clinical trials. A study published in the Journal of Hypertension demonstrated that lercanidipine effectively reduced both systolic and diastolic blood pressure levels in hypertensive patients.

Additional Information

Zanidip is a calcium channel blocker that works by relaxing and widening the blood vessels, allowing for smoother blood flow and reduced blood pressure. It is well-tolerated and has a low incidence of side effects compared to other antihypertensive medications.

Pharmacological Effects: Lercanidipine hydrochloride selectively inhibits calcium ion influx through L-type calcium channels in vascular smooth muscle cells, leading to vasodilation and decreased peripheral vascular resistance. This mechanism helps reduce blood pressure without significant negative inotropic effects on the heart.

Clinical Trials: In a comparative study published in the European Heart Journal, lercanidipine was found to be as effective as other calcium channel blockers in lowering blood pressure with a similar safety profile. The study highlighted the favorable tolerability and cardiovascular outcomes associated with lercanidipine use.