Description
Zanidip (Lercanidipine Hydrochloride) Coated Tablets 20 mg. №28
Ingredients
- Active ingredient: Each tablet contains 20 mg of lercanidipine hydrochloride.
Dosage
- Dosage: The recommended dose is one tablet per day, preferably taken in the morning before breakfast.
Indications
- Indications: Zanidip tablets are indicated for the treatment of essential hypertension in adults.
Contraindications
- Contraindications: Do not use Zanidip if you are allergic to lercanidipine or any other ingredients in the tablets.
Directions
- Directions: Swallow the tablet whole with a glass of water. Do not crush or chew the tablet.
Scientific Evidence
Zanidip (lercanidipine hydrochloride) has shown significant efficacy in lowering blood pressure in clinical trials. A study published in the Journal of Hypertension demonstrated that lercanidipine effectively reduced both systolic and diastolic blood pressure levels in hypertensive patients.
Additional Information
Pharmacological Effects: Lercanidipine hydrochloride selectively inhibits calcium ion influx through L-type calcium channels in vascular smooth muscle cells, leading to vasodilation and decreased peripheral vascular resistance. This mechanism helps reduce blood pressure without significant negative inotropic effects on the heart.
Clinical Trials: In a comparative study published in the European Heart Journal, lercanidipine was found to be as effective as other calcium channel blockers in lowering blood pressure with a similar safety profile. The study highlighted the favorable tolerability and cardiovascular outcomes associated with lercanidipine use.
