Description

Zedan (ceftazidime) powder for solution for injections 1000 mg. vial №1

Ingredients

Active ingredient: Ceftazidime. Inactive ingredients may include sodium carbonate, sodium chloride, and edetate disodium.

Dosage

Dosage: The usual adult dose is 1 to 6 grams daily, administered in divided doses every 8 to 12 hours, depending on the severity of the infection.

Indications

Indications: Zedan is indicated for the treatment of various bacterial infections, including respiratory tract infections, skin and skin structure infections, urinary tract infections, and intra-abdominal infections.

Contraindications

Contraindications: Zedan is contraindicated in patients with a known allergy to cephalosporin antibiotics.

Directions

Administration: Zedan is for intravenous use only. It should be reconstituted with a suitable diluent before administration.

Scientific Evidence

Zedan (ceftazidime) has been extensively studied for its efficacy in treating various bacterial infections. Clinical trials have demonstrated the drug’s effectiveness in combating both gram-positive and gram-negative bacteria. Research published in the Journal of Antimicrobial Chemotherapy showed that ceftazidime is a potent antibiotic with a broad spectrum of activity, making it a valuable option in the treatment of serious infections.

Additional Information

Zedan is a third-generation cephalosporin antibiotic that works by inhibiting bacterial cell wall synthesis, leading to bacterial cell death. It is considered a bactericidal antibiotic, meaning it kills bacteria rather than just inhibiting their growth. The drug is well-tolerated by most patients, with common side effects including diarrhea, nausea, and rash. It is important to complete the full course of treatment as prescribed by a healthcare provider to ensure the infection is fully eradicated.

Pharmacological studies have shown that ceftazidime has a high affinity for penicillin-binding proteins in bacterial cell walls, disrupting cell wall synthesis and leading to bacterial cell lysis. This mechanism of action makes ceftazidime effective against a wide range of bacteria, including those resistant to other antibiotics.

Clinical trials comparing ceftazidime to other antibiotics have shown its comparable efficacy and safety profile. A study published in the International Journal of Antimicrobial Agents found that ceftazidime was as effective as other commonly used antibiotics in the treatment of severe bacterial infections, with a similar incidence of adverse reactions.