Zedan (ceftazidime) powder for solution for injections 1000 mg. vial №1

Description

Zedan (ceftazidime) powder for solution for injections 1000 mg. vial №1

Composition

active substance: ceftazidime;

1 vial contains ceftazidime pentahydrate in terms of ceftazidime 1000 mg;

Excipients: sodium carbonate.

Dosage form

Powder for solution for injection.

Main physical and chemical properties: almost white or yellowish powder.

Pharmacotherapeutic group

Antibacterial agent for systemic use. Cephalosporins of the third generation. ATX code J01D D02.

Pharmacological properties

This tool is an antibacterial drug for systemic use
The active substance is a bactericidal cephalosporin antibiotic. Its action is directed at target proteins of the cell wall, whose mechanism of action is interrelated with changes in the synthesis of bacterial cell walls. The drug has a high intrinsic activity in vitro and has an effect within a narrow range of the minimum inhibitory concentration relative to most pathogens with minimal changes in the MIC at different levels of the inoculum.
Parenteral administration of the drug provides a high and stable concentration of the active ingredient in the serum. Therapeutically effective concentration in blood serum remains even in 8-12 hours after intravenous and intramuscular injections.

Indications

The drug is prescribed for the treatment of mono- and mixed infections caused by sensitive microorganisms:

• sepsis, bacteremia, peritonitis, meningitis;
• infections in patients with reduced immunity;
• in patients of intensive care units, for example with infected burns;
• respiratory infections, including lung infections in patients with cystic fibrosis;
• ENT infections;
• urinary tract infections;
• skin and soft tissue infections;
• infections of the digestive tract, bile ducts and abdomen;
• bone and joint infections;
• infections associated with hemo- and peritoneal dialysis and continuous ambulatory peritoneal dialysis.

Contraindications

The drug in question is contraindicated in cases where the patient has a pronounced hypersensitivity (allergy) to the main or to one of the auxiliary components.
In pediatrics, the drug is used from the first days of life.

Method of application and dose

In most cases, the daily dose is 1-6 g / day every 8 or 12 hours by intravenous or intramuscular injection.
Most infections: 1 g every 8 hours or 2 g every 12 hours.
Genitourinary tract infections and less severe infections: 500 mg – 1 g every 12 hours.
Very severe infections, especially in immunocompromised patients, including patients with neutropenia: 2 g every 8 or 12 hours or 3 g every 12 hours.
For prophylactic purposes in prostate surgery, 1 g should be administered during induction of anesthesia, the second dose is administered at the time of removal of the catheter from the urethra.

Overdose

In case of overdose, the following symptoms are observed:

• encephalopathy;
• convulsions;
• coma.

Side effects

The drug is usually well tolerated when used in the recommended doses.
The following disorders can be observed as side effects:

• candidiasis
• eosinophilia and thrombocytopenia;
• phlebitis or thrombophlebitis at the injection site;
• diarrhea;
• transient increase in liver enzymes;
• maculopapular rash or urticaria;
• pain and / or inflammation at the site of intramuscular injection.