Description

Diclofenak natrium (diclofenac) tablets 0.05 g. №30

Ingredients

Active ingredient: Diclofenac sodium 0.05 g per tablet.

Dosage

Dosage: The usual dose is 1 tablet 2-3 times a day, or as directed by a healthcare professional.

Indications

Indications: Diclofenac is indicated for the relief of pain and inflammation in conditions such as arthritis, ankylosing spondylitis, and acute gout.

Contraindications

Contraindications: Do not use Diclofenac if you have a history of allergic reactions to NSAIDs, peptic ulcer, or renal impairment.

Directions

Directions: Swallow the tablets whole with a glass of water. Do not crush or chew the tablets.

Scientific Evidence

Diclofenac, a nonsteroidal anti-inflammatory drug (NSAID), works by inhibiting the enzyme cyclooxygenase, thereby reducing the production of prostaglandins that cause pain and inflammation. Studies have shown the efficacy of diclofenac in managing various painful conditions, including osteoarthritis and rheumatoid arthritis. Research published in the journal Pain and Therapy demonstrated the superior pain relief provided by diclofenac compared to placebo in patients with osteoarthritis.

Additional Information

Diclofenac tablets should be stored at room temperature away from moisture and heat. It is important to follow the prescribed dosage and not exceed the recommended duration of treatment to avoid potential side effects. If you experience any adverse reactions, consult your healthcare provider immediately.

Pharmacological Effects

Diclofenac exerts its pharmacological effects by inhibiting the enzyme cyclooxygenase, which is involved in the synthesis of prostaglandins. By reducing the levels of prostaglandins, diclofenac helps alleviate pain, inflammation, and fever. Additionally, diclofenac has been shown to inhibit platelet aggregation, making it useful in conditions where clot formation needs to be prevented.

Clinical Trials and Comparative Effectiveness

Clinical trials have demonstrated the efficacy of diclofenac in providing pain relief comparable to other NSAIDs. A study published in the Journal of Clinical Rheumatology compared the effectiveness of diclofenac with ibuprofen in patients with osteoarthritis and found similar improvements in pain and function with both medications. However, diclofenac was associated with a lower risk of gastrointestinal side effects, making it a favorable choice in certain patient populations.