Description

Meloxicam (meloxicam) tablets 15 mg. №20

Ingredients

Each tablet contains 15 mg of meloxicam.

Dosage

The recommended dosage is 15 mg once daily. It is important to follow the instructions provided by your healthcare provider.

Indications

Meloxicam tablets are indicated for the relief of signs and symptoms of osteoarthritis and rheumatoid arthritis. It helps reduce pain, inflammation, and stiffness associated with these conditions.

Contraindications

Do not use meloxicam if you have a history of allergic reactions to NSAIDs. It is contraindicated in patients with active peptic ulcers and severe renal impairment.

Directions

Take the tablet with a full glass of water. Do not crush or chew the tablet. It can be taken with or without food, but it is recommended to take it with food to reduce the risk of gastrointestinal side effects.

Scientific Evidence

Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting the enzyme cyclooxygenase (COX), thereby reducing the production of prostaglandins that cause pain and inflammation. Studies have shown that meloxicam is effective in managing pain and inflammation in patients with osteoarthritis and rheumatoid arthritis. Research published in the Journal of Clinical Rheumatology demonstrated the superior efficacy of meloxicam compared to placebo in improving pain and function in patients with osteoarthritis.

Additional Information

Meloxicam should be used at the lowest effective dose for the shortest duration necessary to control symptoms. Long-term use of NSAIDs may increase the risk of cardiovascular events and gastrointestinal complications. It is important to discuss the risks and benefits of meloxicam therapy with your healthcare provider.

Pharmacological Effects: Meloxicam exhibits anti-inflammatory, analgesic, and antipyretic properties by inhibiting prostaglandin synthesis. It selectively inhibits COX-2 enzyme, which is responsible for inflammation, while sparing COX-1 enzyme, which helps maintain gastrointestinal mucosa integrity.

Clinical Trials: Clinical trials have shown that meloxicam is as effective as other NSAIDs in managing pain and inflammation associated with arthritis, with a lower risk of gastrointestinal side effects. A study published in the Journal of Rheumatology compared the efficacy and safety of meloxicam with diclofenac in patients with rheumatoid arthritis and found similar improvements in disease activity with both drugs.