Description

Nimesin (Nimesulide) Tablets 100 mg. №10

Ingredients

Active ingredient: Nimesulide 100 mg per tablet.

Dosage

Recommended dosage: The usual dose is 100 mg twice daily after meals. Do not exceed the recommended dose.

Indications

Nimesin tablets are indicated for the relief of acute pain, inflammation, and fever associated with various conditions such as osteoarthritis, dysmenorrhea, and acute musculoskeletal disorders.

Contraindications

Do not use Nimesin tablets if you have a history of hypersensitivity to nimesulide or other NSAIDs, active peptic ulcer, severe heart failure, or severe liver or kidney impairment.

Directions

Take Nimesin tablets orally with a full glass of water. It is recommended to take the tablets after meals to reduce the risk of gastrointestinal side effects.

Scientific Evidence

Nimesulide, the active ingredient in Nimesin tablets, has been extensively studied for its analgesic, anti-inflammatory, and antipyretic properties. Research has shown that nimesulide effectively inhibits prostaglandin synthesis, which plays a key role in the inflammatory process. Clinical trials have demonstrated the efficacy of nimesulide in providing rapid and sustained relief from pain and inflammation in various conditions.

Additional Information

Nimesin tablets are well-tolerated by most patients when used at the recommended dose and duration. However, like other NSAIDs, nimesulide may cause gastrointestinal disturbances, renal impairment, and allergic reactions in some individuals. It is important to follow the prescribed dosage and consult a healthcare professional before using this medication, especially if you have any underlying medical conditions.

Pharmacologically, nimesulide selectively inhibits cyclooxygenase-2 (COX-2) enzyme, which is responsible for the production of prostaglandins involved in inflammation and pain. By targeting COX-2, nimesulide reduces inflammation and pain without significantly affecting the COX-1 enzyme, which helps maintain the stomach lining and platelet function.

Comparative studies have shown that nimesulide exhibits similar efficacy to other NSAIDs like diclofenac but with a lower risk of gastrointestinal side effects. Its favorable gastrointestinal safety profile makes it a preferred choice for patients who are prone to stomach irritation or ulcers.