Thioctacid 600 T (α-lipoic acid) solution for injection 600 mg. 24 ml. ampoules №5

Description

Thioctacid 600 T (α-lipoic acid) solution for injection 600 mg. 24 ml. ampoules №5

Composition

active substance: thioctic (α-lipoic) acid;

1 ampoule of solution contains trometamol salt of α-lipoic (thioctic) acid 952.29 mg (equivalent to 600 mg of α-lipoic (thioctic) acid);

Excipients: trometamol, water for injections.

Dosage form

Solution for injection.

Basic physical and chemical properties: transparent solution of yellowish color, practically free from visible particles.

Pharmacotherapeutic group

Drugs that affect the digestive system and metabolic processes. Thioctic acid.
ATX code A16A X01.

Pharmacological properties

This pharmaceutical agent belongs to a group of drugs Thioctacid 600 T solution used in the treatment of certain types of diseases of the digestive system and metabolic processes in the body.
The drug owes its effect to the main therapeutic component – thioctic (lipoic) acid. The name “thioctacid” is also found. This medicinal substance from the group of vitamin-like components is an endogenous antioxidant.
Thioctic acid is an important cofactor and coenzyme involved in the oxidative decarboxylation of alpha-keto acids. Excess blood sugar (hyperglycemia) causes the accumulation of products of accelerated glycolysis, which, in turn, causes a decrease in blood flow and hypoxia, as well as ischemic changes. As a result, free radicals accumulate, damaging peripheral nerves.
Thioctic acid causes a decrease in blood glucose levels. The level of glycogen in the liver also increases. Insulin resistance increases.
Takes part in the regulation of lipid and carbohydrate metabolism, stimulates cholesterol metabolism. It improves liver function, protects its resistance to the effects of free radicals and toxic substances.
It has hepatoprotective, hypolipidemic, hypocholesterolemic and hypoglycemic effects.

Indications

Thioctacid 600 T solution used for the treatment of paresthesias (nervous sensitivity disorders) with complications of diabetes mellitus in the form of diabetic polyneuropathy.

Contraindications

The drug in question is contraindicated for use in cases where the patient has severe hypersensitivity (allergy) to the main or to one of the auxiliary components.
The intake of alcoholic beverages is strictly prohibited.

Application during pregnancy and lactation

This drug is contraindicated in the treatment of pregnant women.
If it is necessary to administer the drug during breastfeeding, then lactation should be suspended for the duration of treatment.

Method of administration and dosage

If the paresthesias are intense, then treatment begins with the infusion of thioctic acid, then switch to oral administration.
12 (24) ml of the drug is diluted in 250 (500) ml of sodium chloride, and this volume of the drug is administered for at least 30 (60) minutes as an intravenous infusion. The bottle with the finished product is protected from sunlight with foil. It can be stored ready-made for up to 6 hours if stored in the refrigerator.
Intravenous injection is also possible. The introduction is performed slowly, at least 12 minutes.
The drug is taken at 300-600 mg of thioctic acid per day (1-2 ampoules, or 12-24 ml of the drug), for 2-4 weeks.
When switching to oral administration in capsules or tablets, take 2 capsules of 300 mg each or 1 capsule of 600 mg of thioctic acid each. If food is taken earlier than 30 minutes later, it will complicate the absorption of the drug.
The total duration of the treatment course is 1-2 months.
During the entire course of treatment, blood sugar levels should be measured regularly, since taking thioctic acid can cause its decrease and hypoglycemic attacks.
It is possible to reduce the dose of insulin administered, depending on the blood sugar level.
At the beginning of the treatment course, a short-term increase in paresthesias in the form of “goose bumps” is possible.

Overdose

Overdose can cause:

• nausea, vomiting;
• headache;
• hypoglycemia;
• shock, hemolysis.

When taken with alcohol – severe intoxication, up to death. It manifests itself in psychomotor agitation, convulsions, lactic acidosis.
Recommended gastric lavage, intake of enterosorbents, hospitalization, treatment of symptoms.

Side effects

In some cases, there may be some side effects in the form of:

• changes and disturbances in taste;
• nausea, vomiting, abdominal pain, diarrhea;
• lowering blood sugar levels, hypoglycemic conditions (dizziness, increased sweating, headaches and visual impairments);
• allergic reactions in the form of skin rash, allergic urticaria, itching, shortness of breath;
• eczema, thrombophlebitis.