Tolperil (tolperisone, lidocaine) solution for injections 1ml. vails №5

Description

Tolperil (tolperisone, lidocaine) solution for injections 1ml. vails №5

Composition

active ingredients: tolperisone, lidocaine;

1 ml tolperisone hydrochloride 100 mg, lidocaine hydrochloride 2.5 mg

Excipients: diethylene glycol monoethyl ether, methyl paraben (E 218), water for injection.

Dosage form

Injection.

Basic physical and chemical properties:
clear, colorless or slightly colored solution.

Pharmacological group

Muscle relaxants of central action.
ATH code M0ZV X04.

Pharmacological properties

This drug belongs to the group of muscle relaxants with central action.
The effect of application is due to the properties of the main active substances – lidocaine, tolperisone hydrochloride.
The drug produces a membrane-stabilizing and local anesthetic effect, some spinal reflexes.
It also has a secondary mechanism of action due to its ability to block the release of the transmitter by blocking the entry of calcium ions into the synapses.
It is able to strengthen peripheral blood circulation, reduce the increase in muscle tone, as well as muscle rigidity, acting as an antispasmodic.
Lidocaine has such a mechanism of action, due to which it has the ability to block sodium channels. Such properties allow to stabilize a neuronal membrane, promoting decrease in its permeability, and stopping ability to conduct impulses. As a consequence, it has a rapid analgesic effect.
Due to the fact that the drug contains several active ingredients, they complement each other, produce an increased effect from its use.

Indications

This drug Tolperil solution is used if necessary to relieve muscle cramps (spasticity). Including for relief of post-stroke spasticity in cases where the injectable form is the method of choice.

Contraindications

Do not use if the patient has a hypersensitivity (allergy) to one of the components that are part of the drug.
Not used for myasthenia gravis.
Contraindicated in pediatrics.

Use during pregnancy and breastfeeding

Treatment of pregnant women with this drug is contraindicated only in the first trimester. In the future, the need for the appointment is determined by the attending physician, based on the benefit / harm ratio.
Lactation should be discontinued during treatment.

Method of application and dose

For parenteral administration only.
It is intended for use only in patients over 18 years of age.
The drug Tolperil solution is administered:

• intramuscularly, 100 mg twice a day.
• intravenously, once a day at 100 mg as a slow injection.

The duration of treatment is determined by the attending physician, depending on the nature of the disease and the effectiveness of treatment, the individual patient’s response to the drug.

Overdose

Symptoms of overdose were observed in cases where the daily dose of the drug (in children) exceeded 300-600 mg per day.
Studies have shown that acute intoxication with high doses caused symptoms such as:

• ataxia;
• tonic-clonic seizures;
• difficulty breathing until it stops.

There is no specific antidote for tolperisone.
In case of overdose, it is recommended to cancel the drug, symptomatic and supportive treatment is prescribed.

Side effects

The following side effects are possible, such as:

• anemia, lymphadenopathy;
• anaphylactic shock, convulsions, tremor;
• anorexia, polydipsia;
• insomnia, depression, headache;
• tremor, convulsions, hyperesthesia, paresthesia;
• tinnitus, vertigo;
• angina, tachycardia, low blood pressure, bradycardia;
• hypotension, redness of the skin;
• difficulty breathing, nosebleeds, shortness of breath;
• diarrhea, dryness of the oral mucosa, dyspepsia, nausea, epigastric pain, constipation, flatulence, vomiting.

If you experience any unusual side effects as a result of taking this drug, you should consult your doctor about possible changes in the treatment regimen.